WD40 repeat 43 mediates cell survival, proliferation, migration and invasion via vimentin in colorectal cancer

Abstract Background WD40 repeat (WDR)43 is an RNA-binding protein that belongs to the WDR domain family. Its biological function largely unclear, particularly in colorectal cancer (CRC). Methods In present study, we searched TCGA database and found correlation between WDR43 CRC. Subsequently, high expression of human clinical samples CRC was validated further examined functions it cells. Finally, explored potential downstream proteins or pathways established subcutaneous xenograft model verify our findings. Results Immunohistochemistry 16 patient specimens confirmed elevated knockdown shown increase apoptosis inhibit proliferation, migration invasion cells vitro reduce tumorigenesis animal models. addition, inhibited vimentin (VIM) overexpression VIM can partially reverse effects both vivo. Conclusion conclusion, role occurrence development investigated study. may serve as a valuable biomarker provide new options for diagnosis treatment cancer.